Monday, April 29, 2013

Grignard reagents.

While writing my formal lab report on Grignard reagents, I tried to get some industrial uses of the reagents so I goggled it and found that, Grignard reaction is a key step in the industrial production of Tamoxifen which is currently used for the treatment of estrogen receptor positive breast cancer in women. Does anyone have an idea how this works? Thank you. 

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3 comments:

  1. AnonymousApril 29, 2013 at 7:52 PM

    Found this...

    http://chemistrypanda.wordpress.com/2012/06/07/how-the-humble-grignard-reagent-came-to-save-so-many-lives/

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    Replies
    1. AnonymousMay 1, 2013 at 12:42 AM

      Thank you for posting this link about the "humble grignard reagent". I am an aspiring oncologist and I find it so fascinating when I understand how seemingly complex drugs actually work. Don't get me wrong, I am sure these pharmaceutical drugs are more complex than I can imagine, but just knowing that I understand a key mechanism in its formation is really exciting! Cool post.

      Delete
  2. AnonymousApril 29, 2013 at 7:52 PM

    and this...

    http://www.ch.ic.ac.uk/local/projects/h_tanner/snyth1.html

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